What is Nytol Original ? Nytol Original 25mg provide temporary relief for sleeplessness by using a common antihistamine as a sedative to help you drift off into your regular sleep rhythm. Why should I choose Nytol Original ? If you’re a bit tired of sleepless nights & looking for a temporary solution that helps you get to sleep, then Nytol Original 25mg could be right for you. How does Nytol Original work ? Let’s get a little sciencey for a second. That commonly used antihistamine we were talking about is diphenhydramine hydrochloride (trust us it’s easier to use than say). It blocks the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This helps reduce alertness & promote that first drowsy stage of sleep. & once in that first stage of sleep, most people drift off naturally into restful deeper sleep.